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KMID : 0358419770200060397
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Korean Journal of Obstetrics and Gynecology
1977 Volume.20 No. 6 p.397 ~ p.403
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Mid-trimester Abortion by Extra-ovular Administration of Prostaglandin F2α
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이수종/Lee SJ
구병삼/서용득/최영송/Koo BS/Suh YD/Choi YS
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Abstract
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The use of prostaglandin F2α administered by extra-ovular infusion through foley catheter for the induction of abortion was studied in 28 patients between 16 and 28 weeks gestation. No serious complications occurred. Some minimal side effects were observed. Occasional vomiting was the commonest symptom but the incidence of side effects was lower than with alternative routes of administration. Side effects were in general well tolerated by the patients and never required therapy or termination. There were 4 cases of incomplete abortion with over 250ml, of estimated blood loss, but transfusion was not required. The method has proved a safe and effective means of terminatimg pregnancies in the second trimester. The results were obtained as follow; 1. The mean abortion time from infusion to the abortion of the fetus was 18.89 hours. The mean abortion time for the multiparas was 17.41 hours, somewhat lower than the mean time for the primiparas of 21.19 hours, but this difference was not statistically significant. 2. the mean total dosage of prostaglandin F2α was 5036.36 ug in primiparas and 4035.29 ug in multiparas. 3. The abortion was successfully induced in 85.7% of patients within 24 hours and in 100% within 36 hours. 4. The most common indication of mid-trimester abortion was psychological problem in 16 cases, next was intraurteine fetal death in 4 cases. 5. the most common side effects consisted of gastrointestinal sysptoms(14.3%) such as nausea, vomiting and diarrhea. Other side effects included transient pyrexia and chilling. 6. The most common disadvantage was incomplete abortion. In 75% of patients, abortion was complete but in 255 of patients was incomplete. These were managed by dilatation and evacuation or manual removal of the placenta.
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